Microfluidic on-demand engineering of exosomes towards cancer immunotherapy
نویسندگان
چکیده
منابع مشابه
Exosomes for cancer immunotherapy.
Exosomes are small vesicles originating from late endosomes and are released in the extracellular medium by a broad array of cells. They were initially described by Johnstone et al. [1] in reticulocytes where multi-vesicular bodies (MVBs) fused with the plasma membrane in an exocytic manner. This exosome secretion was later shown to occur in a wide variety of cell types, including B lymphocytes...
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Exosomes are nanometer sized membrane vesicles invaginating from multivesicular bodies and secreted from epithelial and hematopoietic cells. They were first described "in vitro" but vesicles with the hallmarks of exosomes are present in vivo in germinal centers and biological fluids. Their protein and lipid composition are unique and could account for their expanding functions such as eradicati...
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Peptide-loaded exosomes are promising cancer treatment vehicles; however, moderate T cell responses in human clinical trials indicate a need to further understand exosome-induced immunity. We previously demonstrated that antigen-loaded exosomes carry whole protein antigens and require B cells for inducing antigen-specific T cells. Therefore, we investigated the relative importance of exosomal m...
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ژورنال
عنوان ژورنال: Lab on a Chip
سال: 2019
ISSN: 1473-0197,1473-0189
DOI: 10.1039/c8lc01279b